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Clozapine in Parkinson's Disase Tremor, Effets of Acute and Chronic Administration Neurol 49:1587-1590, Bonuccelli,U.,et al, 1997 See this aricle in Pubmed Article Abstract The effects of the acute administration of clozapine on parkinsonian mixed tremor(i.e.,resting and postural tremors)were evaluated to establish clozapine's predictive value for long-term response and to determine if there is a difference in the pharmacologic responses of the two tremors.A significant reduction of both resting(p<0.05)and postural(p<0.05)tremors was observed under clozapine from the first week of treatment through the entire period of study.There was no statistically significant difference between the degree of improvement for resting and postural tremors after either single or chronic clozapine administration.Sedation was the only side effect reported after clozapine;however,the time courses of sedation and tremor reduction did not coincide in the acute or in the chronic experimental paradigm,where it decreased considerably in a few weeks in all patients.During long-term clozapine treatment,neither systemic side effects nor worsening of motor disability scores were noted.Thus we wish to propose an acute test or a therapeutic attempt,or both,with clozapine before defining a case of mixed parkinsonian tremor as resistant tremor and therefore resorting to a neurosurgical approach.

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